USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P46109 USC-OGP 2-DE database:  P46109 P46109 General information about the entry View entry in simple text format Entry name CRKL_HUMAN Primary accession number P46109 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Crk-like protein;. Gene name Name=CRKL Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0440: pI=6.06; Mw=37741 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0964: pI=5.86; Mw=37969 SPOT OGP-0965: pI=6.06; Mw=37880 Cross-references UniProtKB/Swiss-Prot P46109; CRKL_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CRKL_HUMAN Primary accession number P46109 Secondary accession number(s) A8KA44 D3DX35 Sequence was last modified on  November 1, 1995 (version 1) Annotations were last modified on  March 15, 2017 (version 169) Name and origin of the protein Description RecName: Full=Crk-like protein; Gene name Name=CRKL Encoded on Name=CRKL Keywords 3D-structure; Complete proteome; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X59656; CAA42199.1; -; mRNA EMBL CR456423; CAG30309.1; -; mRNA EMBL AK292909; BAF85598.1; -; mRNA EMBL CH471176; EAX02932.1; -; Genomic_DNA EMBL CH471176; EAX02933.1; -; Genomic_DNA EMBL CH471176; EAX02934.1; -; Genomic_DNA EMBL BC043500; AAH43500.1; -; mRNA CCDS CCDS13785.1; -; . PIR S41754; S41754; . RefSeq NP_005198.1; NM_005207.3; . UniGene Hs.5613; -; . PDB 2BZX; X-ray; 2.80 A; A=237-303 PDB 2BZY; X-ray; 2.50 A; A/B=237-303 PDB 2DBK; NMR; -; A=229-303 PDB 2EO3; NMR; -; A=1-104 PDB 2LQN; NMR; -; A=1-303 PDB 2LQW; NMR; -; A=1-303 PDBsum 2BZX; -; . PDBsum 2BZY; -; . PDBsum 2DBK; -; . PDBsum 2EO3; -; . PDBsum 2LQN; -; . PDBsum 2LQW; -; . ProteinModelPortal P46109; -; . SMR P46109; -; . BioGrid 107789; 109; . DIP DIP-29165N; -; . IntAct P46109; 91; . MINT MINT-137265; -; . STRING 9606.ENSP00000346300; -; . iPTMnet P46109; -; . PhosphoSitePlus P46109; -; . BioMuta CRKL; -; . DMDM 1169094; -; . OGP P46109; -; . EPD P46109; -; . MaxQB P46109; -; . PaxDb P46109; -; . PeptideAtlas P46109; -; . PRIDE P46109; -; . DNASU 1399; -; . Ensembl ENST00000354336; ENSP00000346300; ENSG00000099942; . Ensembl ENST00000411769; ENSP00000396646; ENSG00000099942; . GeneID 1399; -; . KEGG hsa:1399; -; . UCSC uc002ztf.2; human; . CTD 1399; -; . DisGeNET 1399; -; . GeneCards CRKL; -; . HGNC HGNC:2363; CRKL; . HPA HPA000532; -; . HPA HPA001100; -; . MalaCards CRKL; -; . MIM 602007; gene; . neXtProt NX_P46109; -; . OpenTargets ENSG00000099942; -; . Orphanet 261330; Distal 22q11.2 microdeletion syndrome; . PharmGKB PA26881; -; . eggNOG KOG4792; Eukaryota; . eggNOG ENOG4110574; LUCA; . GeneTree ENSGT00820000127055; -; . HOGENOM HOG000236288; -; . HOVERGEN HBG105616; -; . InParanoid P46109; -; . KO K04438; -; . OMA TRMNISG; -; . OrthoDB EOG091G0JPQ; -; . PhylomeDB P46109; -; . TreeFam TF321436; -; . Reactome R-HSA-170968; Frs2-mediated activation; . Reactome R-HSA-186763; Downstream signal transduction; . Reactome R-HSA-8875555; MET activates RAP1 and RAC1; . Reactome R-HSA-8875656; MET receptor recycling; . Reactome R-HSA-912631; Regulation of signaling by CBL; . SignaLink P46109; -; . SIGNOR P46109; -; . ChiTaRS CRKL; human; . EvolutionaryTrace P46109; -; . GeneWiki CRKL; -; . GenomeRNAi 1399; -; . PRO PR:P46109; -; . Proteomes UP000005640; Chromosome 22; . Bgee ENSG00000099942; -; . CleanEx HS_CRKL; -; . Genevisible P46109; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005768; C:endosome; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc; . GO GO:0004871; F:signal transducer activity; TAS:ProtInc; . GO GO:0000186; P:activation of MAPKK activity; TAS:Reactome; . GO GO:0009887; P:animal organ morphogenesis; IEA:Ensembl; . GO GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl; . GO GO:0001568; P:blood vessel development; IEA:Ensembl; . GO GO:0007507; P:heart development; IEA:Ensembl; . GO GO:0035556; P:intracellular signal transduction; TAS:ProtInc; . GO GO:0007254; P:JNK cascade; TAS:ProtInc; . GO GO:0060017; P:parathyroid gland development; IEA:Ensembl; . GO GO:0008284; P:positive regulation of cell proliferation; IMP:CACAO; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:UniProtKB; . GO GO:0007265; P:Ras protein signal transduction; TAS:ProtInc; . GO GO:0048538; P:thymus development; IEA:Ensembl; . Gene3D 3.30.505.10; -; 1; . InterPro IPR000980; SH2; . InterPro IPR011511; SH3_2; . InterPro IPR001452; SH3_domain; . Pfam PF00017; SH2; 1; . Pfam PF00018; SH3_1; 1; . Pfam PF07653; SH3_2; 1; . PRINTS PR00401; SH2DOMAIN; . PRINTS PR00452; SH3DOMAIN; . SMART SM00252; SH2; 1; . SMART SM00326; SH3; 2; . SUPFAM SSF50044; SSF50044; 2; . SUPFAM SSF55550; SSF55550; 2; . PROSITE PS50001; SH2; 1; . PROSITE PS50002; SH3; 1; .

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